Preparation of Ruyijinhuang san pellicle / 中国组织工程研究

ABSTRACT

This study was performed in the Laboratory of Pharmaceutical Department, North China Coal Medical University from November 2005 to May 2006. The effective components in the Ruyi jinhuang san power were extracted with alcohol according to the solubility of the main components in Ruyi jinhuang san. The medical film prepared with chitosan was investigated by comparing with that prepared with Poly (vinyl alcohol). The content of the constituents such as curcumin, rhein, emodin, chrysophanol, and berberine in the film were determined with high pressure liquid chromatography (HPLC). The drug release in vitro of film was determined by Paddle method. Alcohol was an efficient agent for extracting the main components in Ruyijinhuang san, compared to the other solvents. The release rate of rhein in the film was very well, using the release rate of Rbein as an evaluation index. Ruyijinhuang san film prepared with chitosan was flexible and had characteristics of sustained-release in vitro.