Application of mesenchymal stem cells in the treatment of acute radiation injury / 中国组织工程研究

ABSTRACT

It is therapeutically effective to apply hemopoietic growth factors to treat hemopoietic irradiation injuries, but for other tissues injuries, hemopoietic growth factors nearly do not work. At the same time, they are only suitable for the patients with severe and lower level acute radiation sickness (ARS). Besides, clinical therapeutic efficacy of marrow transplantation is not optimistic due to difficulties of marrow zygosity and severe complications such as graft versus host disease, radiation interstitial pneumonitis. Mesenchymal stem cells (MSCs) could secret hemopoietic growth factors, rebuild hemopoietic microenvironment and be easily transfected by exogenous gene, which also have low immunogenicity. At present, studies on MSCs application in the treatment of radiation injuries are at the early -stage, but the precise mechanism is not clear. However, the specific characteristics can make up the disadvantage of traditional treatment of acute radiation sickness, and the clinical application is wide.