Stereoselective bile excretion of ibuprofen glucuronide and the transport mechanism in the biliary efflux / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12): 1163-1167, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-407637
ABSTRACT
AIM:
To illustrate the effects of drug transporters on the bile efflux of ibuprofen glucuronide(IBG), the difference of bile excretion and plasma concentration of ibuprofen(IB) and its glucuronides was studied in EHBR and normal SD rat(SDR).METHODS:
After 20 mg/kg of IB enantiomers administrated intravenously, the bile and blood were collected from the rats and the concentration of IB and their glucuronide were measured by HPLC methods.RESULTS:
The bile excretion of IBG was obviously (but no totally) suppressed in EHBR (1.7%±1.0%, 0.6%±0.9% of the dose respectively for S-IBG and R-IBG) compared with that in SDR (18.4%±4.0% and 3.0%±2.4% of the dose respectively for S-IBG and R-IBG), for both kinds of rats, there are more S-IBG excreted than that of R-IBG. As the result of reduction of IBG excreted in bile, the concentration of IBG was higher in blood in EHBRs.CONCLUSION:
The results suggest that Mrp2 is the most important transporter for IBG, and other transporter(s) may participate in the process.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Pharmacology and Therapeutics
Ano de publicação:
2007
Tipo de documento:
Artigo
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