Effects of low doses 147Pm internal irradiation against hereditary mutation in mouse cells induced by high dose of radiation / 中华放射医学与防护杂志

ABSTRACT

Objective To investigate the effects of low doses 147Pm internal irradiation against hereditary mutation in mouse cells induced by subsequent high dose of 147Pm irradiation. Methods The frequencies of micronucleated polychromatic erythrocytes (mn-PCE) micronucleated normochromatic erythrocytes (mn-NCE) and chromosome aberration in bone marrow and peripheral blood cells were observed. Results The frequencies of nm-PCE、mn-NCE and chromosome aberration induced by high dose of 147Pm irradiation showed a highly significant increase over the control at 24 h after irradiation (P＜0.05 or 0.01).However, the frequencies in cells pre-exposed to 0.37-37 Bq/g of 147Pm were decreased significantly (P＜0.05 or 0.01),as compared with those of the group without pre-exposure. Conclusion Low doses of in vivo 147Pm β-irradiation can induce a radioadaptive response of the lymphocytes and erythroblasts.The induction of the adaptive response has a wide dose range.The mn-PCE and mn-NCE are more sensitive indexes for revealing biological effects of radiation as compared with the chromosome aberration.