Tendinopathy enthesiopathy in athletes / 中国组织工程研究

ABSTRACT

BACKGROUND: Enthesiopathy, one of the three tough problems in sports medicine is a frequent disease in athletes;treatments to enthesiopathy determine the performance record and sports span of athletes in a big extent.DATA SOURCES The relevant articles from 1990 to 2006 were searched for in NCBI Entrez PubMed by input the key words "enthesiopathy" and "tendinopathy" in English into a computer. Similarly, the relevant articles in Chinese from 1994 to 2006 were searched for in CNKI and Wangfang Data.STUDY SELECTION Articles about preclinical and clinical research of enthesiopathy in athlete, the excluded articles were those about repetitive studies.DATA EXTRACTION A total of 20 relevant literatures were collected, including 16 included articles and 4 excluded articles due to repetitive study.DATA SYNTHESIS: ① The main structure of ten-insertion which is very multiplicity contains 4 different tissues, the main function of it is to transmit and absorb shocks. ② So far it is not very clear about the etiopathogenisis and pathological change of enthesiopathy; It is considered that enthesiopathy actually is the result of decompensation in the ten-insertion and degeneration of collagen fiber and cartilaginous is the main pathological change; ③ Nonoperative therapy can abate the clinical symptom, but the curative effect is not affirmative.CONCLUSION: So far it is very clear about the anatomic structure of ten-insertion, but it is not very clear about the etiopathogenisis and pathological change of enthesiopathy and the relationship between enthesiopathy and apoptosis.Scientific and reliable therapies are scarce, strict design and random research of the existing therapies to enthesiopathy are very necessary; for importance, research and exploratory in other therapies including gene therapy and cell factor therapy is a very hopeful direction of the treatment in enthesiopathy.