Technologies for preparation of nanomedicine / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53): 2597-2600, 2007.
Artigo
em Chinês
| WPRIM
| ID: wpr-408006
ABSTRACT
OBJECTIVE:
To clarify the current situation of technologies for preparation of nanomedicine.DATA SOURCES A search of Elsevier database was performed using the key terms "nanomedicine, preparation,nanoparticle, ultrafine powder, microsphere, drug, controlled release" from January 2000 to September 2006. Meanwhile,we also searched the China Journal Full-text Database for the related articles published between January 2000 to September 2006 with the key words "nanomedicine, preparation, powder, microsphere, controlled release" in Chinese.STUDY SELECTION Articles were selected primarily after their abstracts being read, and related articles accorded with the criteria were collected and read entirely.DATA EXTRACTION Totally 268 articles about nanomedcine were collected. Those repetitive or similar researches were excluded, and 38 articles met the research criteria.DATASYNTHESIS:
Nanomedicine consists of macromolecular conjugates and particulate drug carriers. The materials are stable but also degradable and biocompatible. At present, many technologies have been used for preparing nanomedicine, such as, emulsion, microemulsion, ultrasonic solvent-nonsolvent, spay drying and high-pressure homogenization, and so on.CONCLUSION:
The application of nanomedicine carrier and nanotechnology not only sheds a new light on the traditional drugs whose applications are strongly restricted by their poor solubility, high toxicity and poor stability, but also enhances their therapeutic efficiency with lower dosage through targeting effect.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Tissue Engineering Research
Ano de publicação:
2007
Tipo de documento:
Artigo
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