Effects of dietetic fish oil on lipid level of golden hamsters with hyperlipemia / 中国组织工程研究

ABSTRACT

BACKGROUND:There are various reports on the effects of fish oil on lipid level at home and abroad.At present,the related researches domestically are carried on mostly taken rats as the animal model. OBJECTIVE:To study the influence of dietetic fish oil on lipid level of golden hamsters with hyperlipemia. DESIGN:A randomized controlled study. SETTING:The experimental animal center of a teaching hospital affiliated to a university. PARTICIPANTS:The experiment was performed in the Experimental Animal Center of Nanjing General Hospital from June to December 2001.Forty male golden hamsters weighing 70 to 90 g(bought from Shanghai Animal Experiment Center) were randomized into 4 groups with 10 in each, named as the control group,0.5 mL fish oil group,0.8 mL fish oil group and 1.2 mL fish oil group. INTERVENTIONS:The golden hamster models of hyperlipemia were established.Golden hamsters in the control group were treated with saline 1 mL per day,while in the 0.5, 0.8 and 1.2 mL fish oil groups, fish oil of various dosages was applied(0.5,0.8 and 1.2 mL per day) successively to observe the effects on lipid level. RESULTS:In the 0.8 and 1.2 mL fish oil groups, the levers of triglyceride(TG) were(3.91± 2.32) and(6.22± 3.81)mmol/L respectively,which were remarkably reduced as compared with that in the control group[(9.02± 3.90) mmol/L](t=3.46,P< 0.01;t=2.65,P< 0.05). The TG level in the 0.8 mL fish oil group was significantly different from that in the 0.5 mL fish oil group[(8.14± 3.84) mmol/L](t=2.92,P < 0.05).The level of cholesterol and high density lipoprotein(HDL) had insignificant differences(P >0.05). CONCLUSION:Dietetic fish oil acts on reducing blood TG,for which, the effect of the moderate dosage is the best. Its effects in reducing cholesterol and increasing HDL are not apparent.