The Selection of Transdermal Release Condition and Percutaneous Enhancer of Oxaprozin Gel in Vitro / 中国药房

ABSTRACT

OBJECTIVE： To observe the effect of drug loading， medium composition， transdermal enhancer， lauryl alcohol and azone on percutaneous permeation of oxaprozin gel in vitro.METHODS： Drug permeation test was carried out by using modified Franz-type double compartment diffusion cell and isolated mice skin in vitro as transdermal barrier.RESULTS： Under the condition of an effective area of 5.77cm2， it was found that the result was stable and the reproducibility was well with drug loading more than 1.2g， the receiver solution ethanol to normal saline=7∶ 3(v∶ v);The transdermal enhancing effect of lauryl alcohol was superior to that of azone， the effect of mixed transdermal enhancer 3％ AZ＋ 10％ LA was the best.CONCLUSION： The selection of both the optimum release condition and the best penetration enhancers provided reference for oxaprozin transdermal delivery.The standardization of gel percutaneous test in vitro was discussed preliminarily.