Role of endothelin and nitric oxide in the pathogenesis of asthma / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 435-437, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-410414
ABSTRACT
AIM:
To explore whether the balance between endothelin(ET) and nitric oxide(NO) plays an important role in airway hyperresponsiveness of asthmatic rats.METHODS:
The tension of isolated perfused rat tracheal rings was measured after ET-1 stimulation and incubation of JKC 302 and L-NAME.RESULTS:
ET-1 constricted isolated rat tracheal ring, produced slowly developing and long-lasting contraction. The ET-1-induced contraction response of asthmatic rat tracheal ring was higher than that of normal control group (P<0.01). JKC 302, a selective ETA receptor antagonist, partly blocked ET-1-induced contraction in asthmatic rat trachea ring. L-NAME significantly augmented the constriction caused by ET-1.CONCLUSION:
The effects of ET on bronchomotor tone may be modified by NO as this is a bronchomotor, and the imbalance between ET and NO may play an important role in asthma pathogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2001
Tipo de documento:
Artigo
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