Resolution of Racemic Thyroxine with Chiral Additive asMobile Phase by High Performance Liquid Chromatography / 分析化学
Chinese Journal of Analytical Chemistry
;
(12): 406-409, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-410551
ABSTRACT
A high performance liquid chromatographic (HPLC) method using triethylamine (TEA), copper *" acetate and L-proline as the chiral mobile phase (CMP) and the enantiomric analysis of thyroxine (T4) are described. The influence of the mobile phase parameters including the TEA concentration, manipulation pH, concentration of Cu*", concentration of L-proline, temperature of column and flow rate of eluent on the enantiomers separation of thyroxine was studied. The HPLC-CMP is a simple method for separation and determination of D,L-T4 in drug or in human plasma. It can be used to therapeutic drug or adverse drug reactions monitor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Analytical Chemistry
Ano de publicação:
2001
Tipo de documento:
Artigo
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