Expression of Cyclooxygenase-2 in Human Breast Carcinoma: Relevance to Tumor Angiogenesis and Expression of Estrogen Receptor / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 286-295, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-41073
ABSTRACT
PURPOSE:
This study investigates the COX-2 expression in human primary breast carcinomas and its relationship with both angiogenesis and the expression of estrogen receptor. MATERIALS ANDMETHODS:
COX-2 expression, angiogenesis, and estrogen receptor expression were examined by immunohistochemical methods in 167 human breast carcinomas by using monoclonal antibodies against COX-2, CD34, and estrogen receptor protein.RESULTS:
Although COX-2 was expressed in 77.8% of the breast carcinomas (130/167) regardless of histological types, it was not detected at all in benign epithelial cells. Interestingly, COX-2 expression was found to be significantly correlated with tumor angiogenesis (p=0.004), but not with estrogen receptor and other histopathologic parameters.CONCLUSION:
The results suggest that COX-2 expression occurs frequently in breast tissue during transformation of benign epithelial cells to malignant cells regardless of the estrogen receptor status. COX-2 expression may play a role in tumor angiogenesis that is responsible for tumor growth and metastasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Células Epiteliais
/
Estrogênios
/
Ciclo-Oxigenase 2
/
Anticorpos Monoclonais
/
Metástase Neoplásica
Limite:
Humanos
Idioma:
Coreano
Revista:
Cancer Research and Treatment
Ano de publicação:
2001
Tipo de documento:
Artigo
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