The effect of vasoactive substances on synthesis and release of C-type natriuretic peptide in cultured human endothelial cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 193-195, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-410841
ABSTRACT
AIM:
To investigate the effect of endothelin (ET), angiotensin II (AngII) and homocysteine (Hcy) on C-type natriuretic peptide (CNP) synthesis and release.METHODS:
Human endothelial cell was cultured; CNP was measured by radioimmunoassay method.RESULTS:
ET and AngII could augment CNP synthesis in human endothelial cells. Compared with control group, 10-9,10-8,10-7 mol/L ET and Ang II increased CNP content of endothelial cells by 1%(P>0.05), 49%(P<0.05),117%(P<0.01) and 137% (P<0.01),165%(P<0.01),201%(P<0.01),respectively. A great dose of ET and Ang II also stimulated CNP release from cultured human endothelial cells. Hcy had no effect on CNP synthesis, but 10-9,10-8,10-7 mol/L Hcy enhanced CNP release from cultured human endothelial cells by 17%(P>0.05),84%(P<0.01) and 555%(P<0.01), respectively.CONCLUSION:
ET, AngII and Hcy might be involved in the synthesis and release of human endothelial cell CNP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2001
Tipo de documento:
Artigo
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