Changes in brainstem auditory evoked potential and plasma nitric oxide in diabetic rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 251-254, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-410850
ABSTRACT
AIM:
To investigate the role of brainstem auditory evoked potential(BAEP) in the early diagnosis of diabetic central neuropathy (DCN) and to probe into the relationship between plasma nitric oxide (NO) and DCN.METHODS:
Experimental diabetes(ED) rat model was used. BAEP and plasma NO were measured dynamically after ED modeling.RESULTS:
The peak latency (PL) of Ⅰ, Ⅲ, Ⅳ and V and the interpeak latency (IPL) of I-III and III-V of BAEP in ED group prolonged after 4 weeks of ED modeling (P<0.05). All PL and IPL of BAEP prolonged after 6 weeks、8 weeks and 10 weeks (P<0.01). The plasma NO increased to the top in ED group at 2 weeks and then decreased gradually. There was negative correlation between plasma NO and PL and IPL of BAEP.CONCLUSION:
BAEP was sensitive and valuable in the early diagnosis of DCN. Reduction of plasma NO may play a role in the pathogenesis of DCN.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2001
Tipo de documento:
Artigo
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