Affect of ammonium glycyrrhizinate on extracellular matrix of chronic viral hepatitis / 中国新药与临床杂志
Chinese Journal of New Drugs and Clinical Remedies
; (12): 192-194, 2001.
Article
em Zh
| WPRIM
| ID: wpr-410971
Biblioteca responsável:
WPRO
ABSTRACT
AIM:To study the affect of two kind preparations of ammonium glycyrrhizinate on serum extracellular matrix level of chronic viral hepatitis. METHODS: Seventy patients with chronic viral hepatitis were randomly divided into two groups. The first group of 41 patients (M36,F5;age 47a±s 13a) was treated with diammonium glycyrrhizinate 0.15 g, iv, gtt, qd×30 d. The second group of 29 patients (M23,F6; age 48a±12a) was treated with monoamonium glycyrrhizinate 0.2 g iv, gtt, qd×30 d. Serum ECM levels were assayed using RIA method. RESULTS: After treatment the serum ECM levels of both groups reduced remarkably and there was no differance in the reduction of serum ECM levels of the two groups except LN (P<0.05, P<0.01). CONCLUSION: Both preparations of glycyzzhizinate have the efficacy to reduce serum ECM level of chronic viral hepatitis patients and play some role in anti-hepatic fibrosis. Diammonium glycyrrhizinate is more potent than monoammonium glycyrrhizinate.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of New Drugs and Clinical Remedies
Ano de publicação:
2001
Tipo de documento:
Article