Botulinum a toxin treatment of hemifacial spasm and blepharospasm
Journal of Korean Medical Science
; : 334-340, 1993.
Article
em En
| WPRIM
| ID: wpr-41131
Biblioteca responsável:
WPRO
ABSTRACT
We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no improvement with placebo. The peak effect ranged from one to 6 days after injection and mean peak effect was 3.6 days in blepharospasm, and 4 days in hemifacial spasm. Of 144 treatments, 98.6% had excellent results, (below grade I). The duration of beneficial effect ranged 11 to 40 weeks (mean 16.5 weeks) in hemifacial spasm and 9 to 30 weeks (mean 14.2 weeks) in blepharospasm. Complications were encountered in 63.4% in hemifacial spasm and 72.7% in blepharospasm. The common side effects were dry eyes, mouth droop, ptosis and lid edema in order of frequency. These side effects were mild and resolved spontaneously in 1 to 3 weeks. Botulinum A toxin therapy is effective and convenient, and the treatment of choice for patients with hemifacial spasm and blepharospasm.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Espasmo
/
Blefarospasmo
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Toxinas Botulínicas
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Método Duplo-Cego
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Músculos Faciais
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
1993
Tipo de documento:
Article