Study on association of the Beta 3-adrenergic receptor gene wit h obesity / 中华疾病控制杂志
Chinese Journal of Disease Control & Prevention
;
(12): 42-44, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-411686
ABSTRACT
Objective To investigate the association betwee n the β3-adrenergic receptor gene (β3-AR) and obesity. Methods 147 patients with obesity and 106 controls were selected. Genotype of the β 3-AR was determined by polymerase chain reaction (PCR) and restriction fragme nt length polymorphism methods (RFLP). Body mass index (BMI) was detected. Results The frequency of Arg64 allele of β3-AR gene in the obesit y g roup (20.3%) was significantly higher than those in the control group (10.2%) ( P=0.001) . The distribution of Trp64Arg and Arg64Arg genotype in the patient group (38.7% and 0.9%) were both higher than that in the control group (19.0% and 0.7%). In the female subj ects, the Trp64Arg mutation and frequency of Arg64 allele of the β3-AR gene in the obesity group(40.6% and 20.3%) were also higher than those in control (16 . 7% and 9.5%)(P<0.01). Conclusions These results suggest th at the Trp64Arg mutation of the β3-adrenergic-receptor gene may be associat ed with increased body fat.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Disease Control & Prevention
Ano de publicação:
2001
Tipo de documento:
Artigo
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