The expression of lung tissue TGF-β1 in patients with congenital heart disease associated with pulmonary hypertension / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 37-39, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-411855
ABSTRACT
Objectives:
To study the pathological behavior and the value of transforming growth factor β1(TGF-β1) in predicting prognosis in pulmonary hypertension associated with congenital heart disease.Methods:
Lung tissues from 29 patients with congenital heart diseases associated with pulmonary hypertension were examined by surgical biopsy of the lung. All samples were examined for the expression and localization of TGF-β1 by immunohistochemical technique with anti-TGF-β1 antibody.Results:
Twenty-six out of 29 showed positive staining of intracellular endotheliocyte TGF-β1(89.65%),16 samples showed extracellular matrix TGF-β1 staining(55.17%).Statistically, there was significant difference between Ⅰ~Ⅱ and Ⅲ~Ⅵ pathological degrees in extracellular matrix(P<0.05).Conclusions:
TGF-β1 plays an important biological role in the formation of pulmonary hypertension after congenital heart disease. It is conductive in predicting prognosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2001
Tipo de documento:
Artigo
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