Changes of pulmonary malondialdehyde ,glutathione and total-antioxidation content in SD rat with nitrogen dioxide exposure / 医学研究生学报
Journal of Medical Postgraduates
; (12): 15-17, 2001.
Article
em Zh
| WPRIM
| ID: wpr-411862
Biblioteca responsável:
WPRO
ABSTRACT
Objectives:To evaluate lung injury mechanism in SD rat with nitrogen dioxide(NO2) exposure. Methods:In the test-control study, pulmonary malondialdehyde(MDA),glutathione(GSH) and total-antioxidant content(T-AOC) were determined in 10 SD rats with long-term NO2 exposure,10 SD rats with short-term NO2 exposure and 10 SD rats with fresh air as control. Results: Pulmonary MDA content was increased and T-AOC was decreased significantly in SD rat exposed to NO2. Pulmonary GSH was decreased significantly in long-term NO2 exposure group as compared with short-term NO2 exposure group and control group. Conclusions: Imbalance between oxidant and antioxidant was an important mechanism in the pathogenesis of oxidizing lung injury in SD rat with NO2 exposure.
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WPRIM
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Zh
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2001
Tipo de documento:
Article