SYNTHESIS AND ANTICANCER ACTIVITY OF 3-[(3′-METHYL-4′-(SUBSTITUTED PHENYL)-1′,3′-BUTADIENYL] INDOLE DERIVATIVES / 药学学报
Acta Pharmaceutica Sinica
;
(12): 29-33, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-411866
ABSTRACT
AIM To study the synthesis and anticancer activity of 3-[(3′-methyl-4′-(substituted phenyl)-1′,3′-butadienyl] indole derivatives. METHODS Electrophilic-substitution, aldol-condensation, selective-reduction, phase-transfer Wittig reaction and hydrolysis reaction were used in the synthesis of the title compounds. RESULTS Eleven compounds of 3-[(3′-methyl-4′-(substituted phenyl)-1′,3′-butadienyl] indole were synthesized. They are new compounds. Compound 8 showed different inhibitory effects on HL-60, HCT-8 and Bel7402 cell lines in vitro, and its inhibitory rate of antiinflammation was 100% at 10-5 mol*L-1 concentration. CONCLUSION Compound 8 showed high anticancer and antiinflammatory activities, and is worth further studying.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2001
Tipo de documento:
Artigo
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