THE EXPRESSION OF CYCLIND1 AND P21WAF1 IN COLORECTAL CARCINOMA / 中国内镜杂志
China Journal of Endoscopy
;
(12): 15-16, 2001.
Artigo
em Chinês
| WPRIM
| ID: wpr-411969
ABSTRACT
Objective:
To investigate expression of cyclinD1 and p21WAF1 and their relationship with multistage process of colon carcinogenesis.Methods:
Immunohistochemical staining was performed with SP assay on archival materials from 40 colorectal carcinomas,28 colorectal adenomas,and 14 normal mucosa,cyclinD1 and p21WAF1 expression were compared.Results:
The positive staining rate for cyclinD1 in colorectal adenomas and carcinomas is 92.9% and 67.5% respectively,which are both higher than that in the normal mucosa (35.7%) (Padenoma<0.01,Pcarcinoma<0.05) and the expression of cyclinD1 is not correlate with differentiation and lymph node metastasis of colorectal carcinoma.The positive stainimg rate for p21WAF1 in normal mucosa (92.9%) is higher than that in colorectal carcinoma(37.5%) (P<0.01) and the expression of p21WAF1 is correlate with differentiation and lymph node metastasis of colorectal carcinonma.Conclusions:
The aberrant expression of cyclinD1 and p21WAF1 is a common event during multistage process of colon carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Journal of Endoscopy
Ano de publicação:
2001
Tipo de documento:
Artigo
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