Influence of puerarin injection(葛根素注射液) on endothelial functions in patients with variant angina pectoris / 中国中西医结合急救杂志

ABSTRACT

Objective:To observe the curative effects of puerarin injection(葛根素注射液) on variant angina pectoris(VAP) and its influences on endothelial functions.Methods:Fortyeight cases with VAP were randomly divided into treated and control group.The treated group was treated with puerarin injection 300500 mg infused intravenously once a day，meanwhile the control group treated with conventional therapy.The therapeutic course was 1014 days for both groups.Before and after using drugs the changes in endothelin(ET) and nitric oxide (NO) were observed in two groups.Results:In both groups after therapy the clinically symptomatic convalescences and changes in electrocardiography (ECG) compared with before therapy had significant differences,but in comparison between two groups the differences had not statistical significant.Otherwise regarding to the ET and NO the differences were significant between treated group and control group.Conclusions:Puerarin injection not only possesses obviously curative effects on symptomatic convalescence and ECG changes but also is able to improve the endothelial functions.