Regulation of glucocorticoid receptor and its mRNA by Tsiao Shihutang / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1304-1306, 2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-412158
ABSTRACT
AIM:
In order to explore the mechanism of the GC - like effect of Tsiao Shaihutang (TSS), the down - regulation of glucocorticoid receptor and mRNA by TSS were studied.METHODS:
GR sites were determined by receptor radio ligand binding assay method. At the same time, GR mRNA level was determined by quantitative reverse- transcriptive polymerase chain reaction (RT- PCR) method.RESULTS:
(1) GR sites and GR mRNA level were down - regulated significantly after GC, TSS (P < 0.01 ) treatment . (2) GR sites and GR mRNA level in GC plus TSS group were obviously higher than those in GC group (P < 0.01 ).CONCLUSIONS:
These data suggested that TSS can significantly down- regulate GR and GR mRNA level.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2000
Tipo de documento:
Artigo
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