Effect of neuropeptide Y on bcl- 2, bax, fas expressions and proliferation in vascular smooth muscl cells / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1307-1309, 2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-412235
ABSTRACT
AIM:
To explore the effect of neuropeptide Y on expression of apoptosis associated genes and proliferation in vascular smooth muscle cells(VSMC).METHODS:
The proliferation activity of VSMC was dterminded by MTr colorimetry. The average fluorescence intensity that represented VSMC nuclear antigen (PCNA) and bcl -2, bax, fas expressions was quantitatively measured by fluorescence immunohistoehemistry.RESULTS:
Compared with control, the expressions of bcl - 2, bax, fas, PCNA and the VSMC proliferation activity in VSMC treated with NPY were significantly increased.CONCLUSION:
NPY may increase the expression of apoptosis associated genes in VMSC and promote its proliferation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2000
Tipo de documento:
Artigo
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