Immunohistochemical study on androgen receptor in male rat heart / 西安交通大学学报(医学版)

ABSTRACT

ObjectiveTo investigate the influence of aging and castration on the density of andro gen receptor(AR) in the male rat heart. MethodsAR in the heart of rats aged 40d,90d(intact and castrated) and 2 years were demonstrated by means of immunohistochemical technique and the den sity of the positive staining was measured by using image analys is. The optical density of AR in the septum of the rats were analyzed by anova and doncan process of the SAS data analysis system. Re sultsOD(AR) of the group aged 2 years was higher than that of the groups aged 40d and 90d (0. 3550±0. 0077,0. 31080. 0264 and 0. 3149±0. 0200 respectively), thetwolattergroups showed similarly intensive staining, while the value of castrated group(0. 4136±0. 0320) was signif icantly greater than that of intact same aged group. Conclusion The development of sexual gland has little influence in the density of AR in the male rat heart during prepuberty to adult, both old age and castration increase the density of AR in the rat heart.