Effect of Gancyclovir on Proliferation and Differentiation of Chronic MyeloidLeukemia Cells and Research of Its Mechanism / 中国肿瘤生物治疗杂志
Chinese Journal of Cancer Biotherapy
;
(6): 265-268, 2000.
Artigo
em Chinês
| WPRIM
| ID: wpr-412401
ABSTRACT
Objective:
To explore whether gancyclovir (GCV) can inhibit the proliferation and induce the erythro-differ-entiation of the K562 human myeloid leukemia cell line.Methods:
562 cells were cultured with GCV for 4 days to detect cellular changes cloning efficiency, benzidine-positive rate, flow eytometry analysis, and telomerase activity.Results:
When 562 cells grew in the medium containing GCV, the cellular growth and division were gradually suppressed,growth fracture decreased and further differentiation towards the cell producing hemoglobins was found.Conclusion:
GCVcan inhibit proliferation and induce erythro-differentiation of K562 cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Cancer Biotherapy
Ano de publicação:
2000
Tipo de documento:
Artigo
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