Clinical research on correlation between CT-1 and cardiac function in patients with diabetic cardiopathy / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
;
(12): 1156-1158, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-412971
ABSTRACT
Objective To study the eorrelation between the plasma cardiotrophin-1(CT-1)level and cardiac function of patients with diabetic cardiopathy.Methods Using the Biotin-StreptAvidin-enzyme-linked immunosorbent assay(BSA-ELISA),the level of plasma CT-1 jn 35 normal controls,40 patients with type 2 diabetes and 60 patients with diabetic cardiopathy was measured.The relation to heart function was observed.Results The difference of plasma CT-1 level in the three groups was significant(all P<0.05).The level of plasma CT-1 in diabetic cardiopathy group was apparently higher than that of type 2 diabetes group and normal controls(all P<0.01);The level in type 2 diabetes group was significantly higher than that of normal controls(P<0.01).The level of plasma CT-1 elevated with the worsening of heart failure(NYHA classification).The level of plasma CT-1 was correlated with EF(r=0.669,P<0.01);LAD(r=0.528,P<0.01);PVE(r=0.502,P<0.01);CK-MB(r=0.312,P<0.01);TG(r=0.187,P<0.05);DBP(r=0.158,P<0.05)o Stepwise regression analysis revealed that EF and LAD were the most significant agents affecting the plasma CT-1.Conclusion The plasma CT-1 level could reflect the state of cardiac function of diabetic cardiopathy patient,it could help to diagnose diabetic cardiopathy earlier.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Primary Medicine and Pharmacy
Ano de publicação:
2011
Tipo de documento:
Artigo
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