Mutation of P53 tumor suppressor gene in colorectal cancer and its relationship with histologic grade and Dukes' stage / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
;
(6): 140-142, 1999.
Artigo
em Chinês
| WPRIM
| ID: wpr-414767
ABSTRACT
Objective:
To study mutation of Ps3 gene and its relationship with histologic grade and Dukes' stage in colorectal cancer.Methods:
PCR-SSCP was used to detect mutations of Ps3 in 30 colorectal cancer patients.Results:
It was found that 6 mutations (20. 0%) in the coding region of P53 gene. One mutation was located in exon4; 5 mutations were located in exon 5; none of mutation was found in exon 2 and 3. According to the histologic grade of of colorectal cancer,the frequencies of P53 gene mutation were 1/8 (12. 5%) in the well differentiated and in the moderately differentiated as well,3/10 (30. 0%) in the poorly differenctiated and 1/4 (25.0%) in the undifferentiated. In clinic, the frequencies of P53 gene mutation were associated with Dukes stage 1/10 (10. 0 % ) in B stage, 2/12 (16. 7%) in C Stage,3/8(37. 5%) in D stage.Conclusion:
The mutation of P53 gene is related to Dukes' stage,and the P53 gene mutation hardly occurs in exon 2,3 in coloretal cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Jilin University(Medicine Edition)
Ano de publicação:
1999
Tipo de documento:
Artigo
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