The advanced development of Niemann-Pick C1 Like 1 / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6): 373-376, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-415213
ABSTRACT
Identification and characterization of Niemann-Pick C1 Like 1 (NPC1L1) has established NPC1L1 as an essential protein in the intestinal cholesterol absorption process,and NPC1L1 is the molecular target of ezetimibe, which is a cholesterol absorption inhibitor. The expression of the gene and protein of NPC1L1 may be regulated by some nuclear receptors. Lack of NPC1L1 auses a nearly complete protection from the development of atherosclerosis in apoE-/- mice c, which provides new target for the treatment for atherosclerosis and cardiovascular disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Parenteral & Enteral Nutrition
Ano de publicação:
2009
Tipo de documento:
Artigo
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