Effect of limited fluid resuscitation on lung injury in a rat model of hemorrhagic shock / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6): 351-354, 2009.
Artigo
em Chinês
| WPRIM
| ID: wpr-415216
ABSTRACT
Objective:
To compare the effects of traditional and limited resuscitation on mediators of inflammation and the lung injury in a rat model of hemorrhagic shock.Methods:
Seventy-two male Spra-gue-Dawley rats were challenged with hemorrhage followed by unresuscitation or resuscitation with 6 mL/kg blood withdrawl and lactated Ringer's solution of 45 mL/(kg · h) ,30 mL/(kg · h) or 15 mL/ (kg · h). Rats were sacrificed at 24 hrs, 48 hrs and 72 hrs, respectively. Blood was withdrowed for testing plasma levels of lactic acid and TNF-α. Lungs were harvested for observation of the ratio of wet/dry weight and histology.Results:
The unresuscitation group were dead within 2 ~ 12 hrs, while the resuscitation groups were survival. The MAP of group 15 mL/(kg · h) increased slowly, but the MAP of 30 and 45 mL/(kg · h) groups increased rapidly. The plasma levels of TNF-α at 24 and 72 hrs and the lactic acid at 24 hrs in group 45 mL/(kg · h) were higher than that of group 15 and 30 mL/(kg · h) (P < 0. 05). The ratio of W/D weight of lungs at 48 and 72 hrs in group 15 mL/(kg · h) was lower than that of group 45 and 30 mL/(kg · h)(P<0.05). The lung injury was alleviated in pace with the time elapsing. The lung injury was more severe in group 45 mL/(kg · h) than the other two groups in 24, 48 and 72 hrs(P <0. 05).Conclusion:
Limited fluid resuscitation could decrease the plasma levels of TNF-α and lactic acid,and attenuate the lung injury.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Parenteral & Enteral Nutrition
Ano de publicação:
2009
Tipo de documento:
Artigo
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