Relationship of transforming growth factor beta 1 with bone turnover markers and bone mineral density / 中国组织工程研究

ABSTRACT

BACKGROUND: Transforming growth factor-β1(TGF-β1) is an important cytokine in the regulation of bone remodeling. Whether it can be used as a sensitive marker to bone turnover is incompletely understood. OBJECTIVE: To investigate the relationship of TGF-β1 with bone formation and resorption markers, and bone mineral density (BMD) at the anteroposterior lumbar spine. METHODS: Totally 663 healthy women from Changsha were analyzed, aged 20-80 years. Levels of TGF-β1, serum bone alkaline phosphatase (sBAP) and serum C-terminal cross-linked telopeptides (sCTx) were measured by ELISA, at the same time, the BMD of anteroposterior lumbar spine was measured by dual-energy x-ray absorptiometry. The associations between TGF-β1 and other indexes were analyzed. RESULTS AND CONCLUSION: The TGF-β1 levels reached a peak in the 30-39 and 40-49 years groups, which had a negative correlation with age, but no correlation with body mass index (BMI). After corrected for BMI, TGF-β1 was negatively correlated to sBAP and sCTx, but was positively correlated with BMD of spine after correction of BMI or age. TGF-β1 can act as a sensitive cytokine to reflect the changes of bone turnover.