Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone
Clinical Psychopharmacology and Neuroscience
;
: 64-67, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-41576
ABSTRACT
OBJECTIVE:
Prenatal infection is implicated in the etiology of schizophrenia. The objective of this paper is to study the role of complement protein C1q in the psychosis of adult offspring after maternal immune activation (MIA). In addition, effect of 7,8-dihydroxyflavone (7,8-DHF a tropomyosin receptor kinase B [TrkB] agonist) was also examined.METHODS:
Western blot analysis of C1q in the brain regions from adult offspring after prenatal poly(IC) (5.0 mg/kg/day from E12 to E17) exposure was performed. 7,8-DHF or vehicle was given from 4 to 8-weeks old.RESULTS:
Expression of C1q in the prefrontal cortex (PFC) of adult offspring from poly(IC)-treated pregnant mice was significantly higher than that of control group. Early treatment with 7,8-DHF during juvenile and adolescent stages could prevent an increase of C1q in the PFC of adult offspring after MIA.CONCLUSION:
Therefore, it is likely that increased C1q expression in the frontal cortex may play a role in the behavioral abnormalities of adult offspring after MIA. Furthermore, supplementation with a TrkB agonist such as 7,8-DHF during the prodromal stage may have prophylactic effects on the behavioral abnormalities after MIA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosfotransferases
/
Transtornos Psicóticos
/
Esquizofrenia
/
Tropomiosina
/
Encéfalo
/
Proteínas do Sistema Complemento
/
Western Blotting
/
Córtex Pré-Frontal
/
Fator Neurotrófico Derivado do Encéfalo
/
Filhos Adultos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2017
Tipo de documento:
Artigo
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