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The Classification and Clinical Characteristics in Korean Patients with Avellino Corneal Dystrophy
Journal of the Korean Ophthalmological Society ; : 938-944, 2005.
Artigo em Coreano | WPRIM | ID: wpr-41720
ABSTRACT

PURPOSE:

To classify Avellino corneal dystrophy (ACD) into 3 groups by slit lamp photography and to evaluate the inter-group differences.

METHODS:

DNA analysis was performed in one member from each of 45 families who were clinically diagnosed as ACD. Corneal opacities were classified into mild (group I), moderate (group II), and severe (group III) based on slit lamp photograph.

RESULTS:

Six patients were confirmed as homozygous ACD and ninety-two as heterozygous ACD. One homozygous patient was revealed to have a novel phenotype. The age increased with increasing severity, and the proportion of females in group III was significantly higher than that of the other two groups (p=0.001). The prevalence of laser in situ keratomileusis (LASIK) increased in group III (p=0.001), and the incidence of pterygium increased in group I compared with the other two groups (p=0.025).

CONCLUSIONS:

ACD was aggravated with age, while pterygium and LASIK altered the natural course of ACD.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Pterígio / DNA / Fotografação / Incidência / Prevalência / Classificação / Opacidade da Córnea / Ceratomileuse Assistida por Excimer Laser In Situ Tipo de estudo: Estudo de incidência / Estudo de prevalência / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Pterígio / DNA / Fotografação / Incidência / Prevalência / Classificação / Opacidade da Córnea / Ceratomileuse Assistida por Excimer Laser In Situ Tipo de estudo: Estudo de incidência / Estudo de prevalência / Estudo prognóstico Limite: Feminino / Humanos Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Ano de publicação: 2005 Tipo de documento: Artigo