Value of detection of fecal Alu repetitive sequences in the diagnosis of pancreatic cancer / 中华胰腺病杂志
Chinese Journal of Pancreatology
;
(6): 383-385, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-417611
ABSTRACT
ObjectiveTo detect the Alu expression in the stool of patients with pancreatic cancer and investigate its value in the diagnosis of pancreatic cancer.MethodsStool samples were obtained from patients with pancreatic cancer (PC) ( n =41 ),chronic pancreatitis (CP) ( n =27 ) and healthy subjects ( n =23 ),the DNA was extracted from the stool and the expression of Alu repetitive sequences was subjected to quantitative analysis by the real-time PCR.ResultsThe expressions of Alu repetitive sequences in PC,CP,and healthy subjects were (5.17 ± 0.99 ),( 3.79 ± 0.94),(0.28 ± 0.35 ) rig/g,and the difference among the three groups was statistically significant (P <0.05).The AUC of PC was 74.8% with the 95% CI 0.661 ~0.835,and the sensitivity,specificity was 75.6% and 67.1%,respectively.ConclusionsAlu repetitive sequences are highly expressed in the stool of patients with pancreatic cancer,and it is of value in the diagnosis of pancreatic cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Pancreatology
Ano de publicação:
2011
Tipo de documento:
Artigo
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