Value of interleukin (IL)-6 and IL-10 in the sepsis secondary to pneumonia in children / 中国小儿急救医学

ABSTRACT

Objective To determine the changes of the host's inflammatory response throughout the course of sepsis secondary to pneumonia by evaluating the serum levels of interleukin (IL)-6 and IL-10.Methods Sixty-two patients who were diagnosed with pneumonia and hospitalized in PICU from Sep 2008 to Mar 2009 were enrolled in this study.They were divided into 3 groupspneumonia group (n =31 ),sepsis group (n =20) and severe sepsis group (n =11 ).The serum levels of IL-6 and Il-10 were measured by enzyme-linked immunosorbent assay at the day 1 and day 4 after admitted to PICU.Results The pediatric risk of score mortality Ⅲ scores and fatality rate were significantly higher in severe sepsis group compared to the other two groups (P ＜ 0.05).The levels of IL-6 were (55.68 ± 61.41 ) pg/ml,(57.46 ± 96.56) pg/ml,and ( 114.86 ± 206.37) pg/ml in pneumonia group,sepsis group and severe sepsis group at day 1 of PICU,with no difference among 3 groups.However,the levels of IL-10 were ( 59.50 ± 57.97 ) pg/ml,( 41.27 ±28.37) pg/ml,and(20.05 ±9.14) pg/ml at day 1 in 3 groups,which showed a significant difference(P ＜0.05).The ratio of IL-6 to IL-10 were 1.51 ±2.42,1.48 ±2.50,and 14.47 ±26.97 at day 1 in 3 groups.There was a significant differrence among 3 groups ( P ＜ 0.05 ).No difference was found among 3 groups at day 4.Conclusion IL-10 may be an determinant factor of the severity and prognosis of the sepsis,and measurement of IL-10 or the ratio of IL-6 to IL-10 can be used to evaluate the severity and prognosis of sepsis.