Oxidative stress and bronchopulmonary dysplasia / 国际儿科学杂志

ABSTRACT

Bronchopulmonary dysplasia( BPD),a serious disease in premature infant,obviously reduces the quality of life in the survivors.The etiological factors and pathological mechanism of BPD are very complicated.BPD caused by hyperoxia is associated with imbalance between the ability of antioxidation and the oxidation in body.There is a very close relationship between oxidative stress and inflammatory reaction,which influence each other and play a critical role in the development of BPD.Reactive oxygen species as a second message regulate many nuclear factors related to the proliferation and apoptosis of cells,which probably are the important mechanisms that oxygen stresses promote the development of BPD from gene level.The intervention of prevention and treatment in BPD are still at the exploration stage.This paper summarizes the intrinsic link between oxidative stress induced by high concentration oxygen and BPD,and the prevention and treatment in BPD by antioxidant.