Your browser doesn't support javascript.
loading
Clinical research on expression levels of T lymphocytes and NK cells in patients with esophageal cancer treated with radiotherapy / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 674-677, 2011.
Artigo em Chinês | WPRIM | ID: wpr-419955
ABSTRACT
Objective To study the relationship between the change of T lymphocyte subsets and NK cells in esophageal cancer patients and radiotherapy effect.Methods The levels of T lymphocyte subsets and NK cells were detected by flow cytometry in 56 cases with histologically confirmed esophageal cancer treated with radiotherapy and contrasted to the healthy people.Results In patients with esophageal cancer,peripheral blood T cells,Th cells,Th / Ts were decreased significantly compared with the control group [(58.3±5.2) % vs (65.8±7.2) %,(28.7±5.0) % vs (38.1±7.7) %,(1.0±0.3) vs (1.6+2.7),all P < 0.05],while the Ts cells were significantly increased [(28.8±5.3) % vs (25.4±5.7) %,P < 0.05].There was no significant difference between peripheral blood T lymphocyte subsets,Th/Ts ratio change and patient age,sex,tumor staging,histological differentiation and pathological lesions.After radiotherapy,the levels of peripheral blood T cells,Th cells,Th/Ts cell ratio and NK cells in esophageal cancer patients were increased [(66.9±4.5) % vs (59.4±4.9) %,(40.6±5.6) % vs (29.1±4.2) %,(1.6+0.5) % vs (1.0±0.4) %,(16.2±3.9) % vs (14.6±3.2) %,all P < 0.05],while the Ts cells decreased [ (25.4±3.6) % vs (28.4±5.7) %,P < 0.05].The increasing degree of peripheral blood T cells,Th cells were closely related to the lesion progress,the difference was significant (both P < 0.05).Conclusion Cellular immune function in patients with esophageal cancer is low.Detection of T lymphocyte subsets,NK cells can be used for immune monitoring of patients with esophageal cancer.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2011 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2011 Tipo de documento: Artigo