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Study on cisplatin combination with pemetrexed disodium in the therapy for malignant pleural mesothelioma / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 736-738, 2011.
Artigo em Chinês | WPRIM | ID: wpr-420010
ABSTRACT
Objective To explore the clinical efficacy of ALIMTA (pemetrexed disodium) plus cisplatin.Methods Patients with malignant mesothelioma were allocated to two treatment groups envelopepemetrexed plus cisplatin (PEM-group) or cisplatin alone (DDP-group).Results A total of 64 patients were randomly assigned and evaluated.The number of patients in PEM- and DDP-group had a significant pathologic complete response were (56.25 % vs 21.88 %,x2 =7.943,P <0.05).Progression-free survival was significantly higher in PEM-group (P <0.05),and 2-year survival rate was lower in DDP-group (P <0.05).Conclusion Pemetrexed elicit significant tumor response and delays disease progression compared with DDP alone in patients with advanced MPM.Improvement in OS is seen in this study.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Cancer Research and Clinic Ano de publicação: 2011 Tipo de documento: Artigo