Expression and clinical pathological significance of CXCR4 and HIF-1α protein in esophageal squamous cell carcinoma / 肿瘤研究与临床
Cancer Research and Clinic
;
(6): 772-774, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-420041
ABSTRACT
Objective To investigate the expression and clinicopathological significance of CXCR4 and HIF-1α protein in esophageal squamous cell carcinoma tissue and explore their correlation.Methods The expression of CXCR4 and HIF-1α protein were assessed by immunohistochemistry SP method in 56 cases with esophageal squamous cell carcinoma and in 20 cases with surrounded normal tissue.Results The expressions of CXCR4 and HIF-lα in esophageal squamous cell carcinoma were significantly higher than those in normal tissues[62.50 % (35/56) vs 10.00 % (2/20); 57.14 % (32/56) vs 0(0/20)](x2=16.259,19.740,P <0.01).The expression of CXCR4 and HIF-1α were both correlated with invasion depth (x2 =4.736,7.665,P <0.05) and lymph node metastasis ( x2 =7.207,6.389,P <0.05),and had no correlation with cancer cell differentiation.The expressions of CXCR4 and HIF-lα in esophageal squamous cell carcinoma were positively correlated (r =0.298,P <0.05).Conclusion CXCR4 and HIF-1α are highly expressed in esophageal squamous cell carcinoma.The two have a close relation to esophageal squamous cell carcinoma growth,invasion and metastasis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Cancer Research and Clinic
Ano de publicação:
2011
Tipo de documento:
Artigo
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