The detection and analysis of serum homocysteine and cystatin C level in patients with malignancy / 中国基层医药

ABSTRACT

Objective To investigate the expression of homocysteine and cystatin C in the serum of patients with different types of malignant tumors.Methods 120 patients with malignant tumors were divided into group A (gastric cancer),group B (esophageal canler),group C (liver cancer) and group D (nasopharyngeal carcinoma) according to the type of disease,25 healthy volunteers were selected as control group.Enzyme-linked immunosorbent (ELISA) was used to measure serum homocysteine and cystatin C levels in four groups of patients.Results Homocysteine level of group A,group B,group C and group D were (19.71 ± 3.40)μmol/L,(23.27 ± 9.57)μ mol/L,(21.37 ±0.38) μmol/L and (16.27 ± 1.24) μmol/L,which were significantly higher than those of the control group (all P ＜ 0.05).Cystatin C levels of group A,group B,group C and group D were (19.71 ± 3.40) mg/L,(19.71 ±3.40) mg/L.(19.71 ± 3.40) mg/L and (19.71 ± 3.40) mg/L,which were significantly higher than those of the control group (all P ＜ 0.05).Serum homocysteine and cystatin C levels of gastric cancer positively correlated with carcinoembryonic antigen (CEA) level(r =0.9643,0.9842).However,serum homocysteine and cystatin C levels of esophageal cancer,liver cancer and nasopharyngeal carcinoma had no correlation with serumCEA level.Conclusion Cystatine C and homoeysteine have potential clinical value on the diagnosis of malignant tumors.