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A Clinical Study on Kanglaite injection combined with comprehensive therapy in the treatment of patients with advanced non-small cell lung cancer / 中国综合临床
Clinical Medicine of China ; (12): 1236-1239, 2012.
Artigo em Chinês | WPRIM | ID: wpr-420593
ABSTRACT
Objective To study the effect of Kanglaite combined with comprehensive therapy on advanced non-small cell lung cancer.Methods Sixty-one patients with advanced non-small cell lung cancer were randomly divided into treatment group ( n=31 ) and control group ( n=30 ).Both groups were given comprehensive therapy.Treatment group were additionally treated with intravenous injection of 200 ml Kanglaite.Clinical efficacy,quality of life,pain relief and adverse reactions of the two groups were observed.Results ( 1 ) Quality of life was improved in 20 cases (64.5% ),stabled in 8 cases (25.8%),declined in 3 cases ( 9.7% ) of treatment group,and in the control group there were 9 cases ( 30.0% ) improved,9 cases ( 30.0% ) stabilized,12 cases (40.0% ) declined respectively.Quality of life in treatment group was higher than in control group ( U=2.91,P<0.01 ).( 2 ) Pain reliefthe number of patients with complete remission,partial remission,no change,and progression were 5 cases ( 16.1% ),16 cases ( 51.6 % ),16 cases (51.6% ),6 cases (19.4%) and 4 cases (12.9% ) in treatment group,and in control group they were 2 cases(6.7% ),9 cases (30.0% ),11 cases(36.7% ) and 8 cases(26.7% ) respectively.The effect of treatment on pain relief in treatment group was better than that in control group ( U=2.32,P<0.05 ).(3) Clinical efficacyin the treatment group there were 12 cases (38.7%) with partial remission,14 cases (45.2%) stabilized,and 5 cases (16.1% ) progressed,and in control group the numbers were 8 cases (26.7% ),8 cases (26.7% ) and 14 cases (46.7% ) respectively.The clinical efficacy in treatment group was better than that in the control group( U=2.04,P<0.05).(4) There were significant difference on the change of white blood cell count and gastrointestinal reactions Ⅲ and Ⅳ degrees between treatment group and contrl group [22.6% (7/31) vs.53.3%(16/30),x2=6.139 P<0.05;19.4% (6/31) vs.46.7% (14/30),x2=5.161,P<0.05].Conclusion Kanglaite injection combined with comprehensive therapy can improve clinical efficacy of therapy for advanced non-small cell lung cancer,reduce the toxic adverse reaction,protect immunity system and improve the quality of life of patients.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Clinical Medicine of China Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Clinical Medicine of China Ano de publicação: 2012 Tipo de documento: Artigo