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HDL-Associated Paraoxonase 1 as a Bridge between Postmenopausal Osteoporosis and Cardiovascular Disease / 전남의대학술지
Chonnam Medical Journal ; : 75-81, 2014.
Artigo em Inglês | WPRIM | ID: wpr-42139
ABSTRACT
The association of postmenopausal osteoporosis (PMOP) with both atherosclerosis and vascular/valvular calcification is well known. Recently, ample evidence has suggested a common etiologic factor, namely, reduced HDL-associated paraoxonase 1 (PON1) activity, as a causative factor in the development of PMOP and cardiovascular disease (CVD). This common etiologic factor not only contributes to atherosclerotic diseases but also to PMOP following an almost identical mechanism including dysfunctional HDL and lipid oxidation. According to recent studies, lipid oxidation might improve osteoblastic transformation of vascular cells and obstruct such transformation in bone cells. The primary objective of this current review was to summarize the evidence revealing the role of HDL-associated PON1 enzyme in PMOP. Additionally, the review aimed to address some of the subjects that need further investigation in order to define whether hyperhomocysteinemia and sensitivity to lipid oxidation may be risk factors for PMOP.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoblastos / Osteoporose / Menopausa / Doenças Cardiovasculares / Osteoporose Pós-Menopausa / Fatores de Risco / Estresse Oxidativo / Hiper-Homocisteinemia / Arildialquilfosfatase / Aterosclerose Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Chonnam Medical Journal Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Osteoblastos / Osteoporose / Menopausa / Doenças Cardiovasculares / Osteoporose Pós-Menopausa / Fatores de Risco / Estresse Oxidativo / Hiper-Homocisteinemia / Arildialquilfosfatase / Aterosclerose Tipo de estudo: Estudo de etiologia / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Chonnam Medical Journal Ano de publicação: 2014 Tipo de documento: Artigo