Expression of matrix metalloproteinase-2,cysteine rich protein61 and CD25 In esophageal carcinoma and their significance / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 27-29, 2011.
Article
em Zh
| WPRIM
| ID: wpr-421529
Biblioteca responsável:
WPRO
ABSTRACT
ObjectiveTo determine the expression of matrix metalloproteinase-2 (MMP-2),cysteine rich protein 61 (Cyr61) and CD25 in esophageal carcinoma and investigate their clinical significance.MethodThe expression of MMP-2, Cyr61 and CD25 in 68 cases of esophageal tumor tissues (esophageal carcinoma group ) and part-cancer( para-cancer group ) and 68 cases of reflux esophagitis (control group ) was detected by immunohistochemical method and the results were statistically analysed. ResultsThe positive expression rates of MMP-2,Cyr61 and CD25 were 82.35%(56/68), 73.53%(50/68) and 89.71%(61/68)respectively in esophageal carcinoma group,there were significant differences compared with those in paracancer group and control group(P < 0.05) ; while there was no significantdifference between para-cancer group and control group (P > 0.05 ). The positive expression rates of MMP-2, Cyr61 and CD25 in esophageal carcinoma group in different T stage, N stage and M stage all had statisticall differences (P < 0.05),while there was no significant difference in different degree of differentiation (P > 0.05 ). ConclusionMMP-2,Cyr61 and CD25 is highly expressed in esophageal carcinoma,there is some significance for understanding the occurrence, development and prognosis of esophageal carcinoma.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Postgraduates of Medicine
Ano de publicação:
2011
Tipo de documento:
Article