New progresses of microRNAs researches in breast cancer and breast cancer stem cells / 国际外科学杂志

ABSTRACT

microRNAs play a critical role in breast tumorigenesis and progression, in which it might serve as oncogene, tumor suppressor gene, regulators of invasion, apoptosis and therapy resistance. Moreover,there has been a large body of evidences for the involvement of miRNAs in the self-renewal, differentiation and tumor formation of breast cancer stem cells. This review respectively summarizes the relations between microRNAs and breast cancer, breast cancer stem cell as well as the progresses of applying microRNAs to tumor therapy.