Clinical application of amiodarone combined with benazepril to paroxysmal atrial fibrillation / 中国基层医药

ABSTRACT

ObjectiveTo observe the clinical application of amiodarone combined with benazepril to paroxysmal atrial fibrillation. Methods80 patients were randomly divided into observation group and control group of 40 caess ,the control group only used amiodarone treatment and observation group used amiodarone combined with benazepril,compared 24h, 1、3、6、12months after treatment, sinus rhythm conditions and adverse reactions. ResultsThe observation group in sinus rhythm cardioversion rate was 20.0％ (8/40), control group was 15.0％ (6/40) ,it had no significant difference between the two groups at 24h( x2 =0. 346 ,P =0. 556) ;observation group in sinus rhythm cardioversion rate was 57.5％ ( 23/40 ) ,67.5％ ( 27/40 ) ,62.5％ ( 25/40 ) ,57.5％ ( 23/40 ), the control group was 32. 5％ (13/40) ,40.0％ (16/40) ,27.5％ (11/40) ,30.0％ ( 12/40 ) at 1,3,6,12 months, it had statistically difference betweem the two groups ( x2 =5.051,6.084,9.899,6.146, P =0. 025 ,0. 014 ,0. 002 ,0. 013 ). 1 case of observation group with gastrointestinal discomfort, 3 cases of control group with nausea and vomiting occurred in,4 cases with bradycardia,2 cases with QT interval prolongation,the incidence of adverse reactions in observed group was lower than the control group( x2 =5. 600,P =0.018). ConclusionThe clinical effect of amiodarone combined with benazepril treatment of paroxysmal atrial fibrillation was better than amiodarone alone,it could effectively reduce the adverse reaction, so it was worthy of attention.