The correlation of serum interleukin-6, interleukin-10 and tumor necrosis factor-α concentrations and the prognosis of sepsis in children / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 406-407, 2011.
Artigo
em Chinês
| WPRIM
| ID: wpr-422110
ABSTRACT
Objective To investigate the correlation of serum concentrations of interleukin(IL)-6,IL-10 and tumor necrosis factor(TNF)-α and the prognosis of sepsis in children.Methods Fifty-seven septic patients in PICU were enrolled in the study,of whom 44 patients survived(sepsis survival group),13 patients died(sepsis dead group).Another 65 cases of non-sepsis patients served as control(non-sepsis group).The critical illness score,the number of damaged organs,and serum levels of IL-6,IL-10,TNF-α,IL-6/IL-10,TNF-α/IL-10 in each group were compared.Results The critical illness score was decreased and the number of damaged organs was more in sepsis dead group than those in non-sepsis group and sepsis survival group.Compared with non-sepsis group and sepsis survival group,the expression of IL-6 and IL-10 increased,TFN-α/IL-10 ratio significantly decreased in sepsis dead group(P < 0.05),but the difference between the sepsis survival group and non-sepsis group was not statistically significant(P > 0.05).The serum levels of TNF-α and IL-6/IL-10 ratio showed no significant difference among three groups(P > 0.05).Conclusion In sepsis patients,the serum concentrations of IL-6,IL-10 are higher and the TNF-α/IL-10 ratio is smaller,the prognosis is worse.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Pediatric Emergency Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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