Expression and significance of matrix metalloproteinase-2 and basic fibroblast growth factor in human glioma / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 32-34, 2011.
Article
em Zh
| WPRIM
| ID: wpr-422303
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the expression and significance of matrix metalloproteinase-2 (MMP-2) and basic fibroblast growth factor (bFGF) in human glioma.Methods The expression levels of bFGF and MMP-2 in 56 cases of human glioma and 9 cases of normal brain tissue specimen were detected by immunohistochemistry technique.Furthermore,the correlation between the expression of the bFGF and MMP-2 was compared.Results In normal brain tissue,grade Ⅰ,Ⅱ and grade Ⅲ,Ⅳ,the positive expression of bFGF were (9.51 + 2.69)%,(24.78 ±- 7.57 )%,(41.23 ± 12.35 )%,respectively,and MMP-2were (7.18 ± 2.12)%,(21.56 ± 3.85 )%,(54.32 + 7.32)%,respectively.The differences were significant among them (P <0.05).bFGF and MMP-2 were positive correlated (r =0.71,P <0.01).Conclusions There is an intrinsic correlation between the expression of the bFGF and MMP-2 and histological grade of human gliomas.These findings suggest that the synergistic interaction of bFGF and MMP-2 play an important role during the tumor invasion.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Postgraduates of Medicine
Ano de publicação:
2011
Tipo de documento:
Article