Prevalence of metabolic syndrome in patients with schizophrenia and its related factors / 中华行为医学与脑科学杂志

ABSTRACT

ObjectiveTo investigate prevalence of metabolic syndrome (MS) and related factors in patients with schizophrenia.MethodsFive hundred and three inpatients with schizophrenia and 60 healthy volunteers were included in this study.The demographic information and medical data of these participants were recorded,and their physiological and biochemical parameters were measured,the MS was diagnosed according to CDand IDF criteria.ResultsThe MS prevalence in patients with schizophrenia was 12.1％ according to CDS criteria and 28.4％ based on IDF standard,significantly higher than control group; the prevalence of MS was higher among female patients ( 15.3％ or 39.8％ ) than male patients ( 10.4％ or 22.4％ ) ; the prevalence of MS was higher among patients aged 40 or over ( 14.3％ or 30.9％ ) than patients aged 40 below (6.4％ or 22.1％ ).Dyslipidaemia (elevated TG and reduced HDL-C),obesity (BMI and waist) and increased blood glucose were the most important risk factors ( OR value ＞ 6.0),increased total cholesterol,high blood pressure,elevated LDL-C,increased uric acid,female,in marriage,and paranoid type were also important risk factors (OR value ＞ 2.0).Stepwise discriminate analysis showed triglyceride (0.569),BMI (0.451 ),HDL-C ( -0.298 ),gender (0.297 ),age (0.294)and LDL-C (0.210) 6 factors had a separate identification role in MS.ConclusionThe prevalence of MS in patients with schizophrenia in significantly higher than that in the general population,females are higher than males in the patients with patients,and older patients are higher than younger patients.Dyslipidemia,obesity and elevated blood glucose are the most important risk factors and predictors of the MS.