Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor / 소아과
Korean Journal of Pediatrics
; : 1079-1085, 2006.
Article
em Ko
| WPRIM
| ID: wpr-42312
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor. METHODS: From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and ASCTs were retrospectively analyzed. RESULTS: The single most powerful predictor of neutrophil and platelet recovery was the number of transplanted CD34+ cells. The duration of high fever was significantly longer in young patients, in patients treated with total body irradiation and/or thiotepa, and in patients transplanted with lower CD34+ cell dose(1x10(6)/kg per transplantation. Therefore, it is important not to defer the appropriate time for HDCT for an additional collection of hematopoietic stem cells if the number of collected CD34+ cells is >1x10(6)/kg per transplantation.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Células-Tronco
/
Plaquetas
/
Células-Tronco Hematopoéticas
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Irradiação Corporal Total
/
Tiotepa
/
Transplante de Células-Tronco
/
Tratamento Farmacológico
/
Febre
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2006
Tipo de documento:
Article