Clinicopathological features and prognosis of hepatocellular-cholangiocarcinoma: a study of 12 patients / 中华肝胆外科杂志

ABSTRACT

Objective To study the clinical and pathological characteristics of hepatocellularcholangiocarcinoma,and standardize the diagnosis and treatment strategy.Methods Between January 1990 to October 2010,12 patients with hepatocellular-cholangiocarcinoma were treated at Peking Union Medical College Hospital (PUMCH).A retrospective study was performed based on the clinical data of these patients to evaluate the diagnosis,curative treatment and prognosis.Kaplan-Meier estimate was employed for survival analysis and log-rank test for group comparisons.Results There were ten male and 2 female patients,with a mean age of 51±6.3 (range,40 to 59).Abdominal pain,fatigue and weight loss were the main symptoms.Eleven of 12 (91.7％) patients had chronic hepatitis B,and 10 (83.3％) had cirrhosis.None of the 12 patients was accurately diagnosed preoperatively.The 1,3,and 5-year overall survivals for 11 patients who were regularly followed up were 63.6％,27.2 ％ and 9.1 ％,respectively.Conclusions The clinical manifestations of hepatocellular-cholangiocarcinoma were diverse,which led to preoperatively misdiagnosis.The diagnosis was made on pathological examination.Surgical resection was the main treatment.The prognosis of hepatocellularcholangiocarcinoma was bad.