Roles of microRNA in tumor angiogenesis-relative signaling pathways / 国际肿瘤学杂志

ABSTRACT

MicroRNAs(miRNAs) are small non-coding RNAs of 20-24nt(about 22nt) in length that mediate gene expression at the post-transcriptional level by degrading or repressing target messenger RNAs (mRNAs).Angiogenesis plays an important role in occurrence and development of cancers which involves multiple signaling pathways.miRNAs can regulate the signaling pathways in which their target genes are involved.Therefore,to study the miRNAs regulation of tumor angiogenesis slgnaling pathways will contribute to cancer diagnosis and treatment.